Cysteine glutathionylation acts as a redox switch in endothelial cells

A Lermant, CE Murdoch - Antioxidants, 2019 - mdpi.com
Oxidative post-translational modifications (oxPTM) of receptors, enzymes, ion channels and
transcription factors play an important role in cell signaling. oxPTMs are a key way in which …

[HTML][HTML] Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial …

XJ Chen, L Wang, XY Song - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Chemotherapy drugs such as vincristine (Vin) could cause neuropathic pain. However, it is
still lack of ideal therapeutic strategy to treat it. Mitochondrial dysfunction has been involved …

[HTML][HTML] GPR43 regulation of mitochondrial damage to alleviate inflammatory reaction in sepsis

W Zhang, W Wang, M Xu, H Xie, Z Pu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Sepsis is a common critical illness in ICU and always a great difficulty in clinical treatment.
GPR43 (G protein-coupled receptor 43) participates in regulating appetite and …

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis

ZA Rizvi, P Babele, S Sadhu, U Madan… - Frontiers in …, 2022 - frontiersin.org
Severe coronavirus disease (COVID-19) is accompanied by acute respiratory distress
syndrome and pulmonary pathology, and is presented mostly with an inflammatory cytokine …

NADPH Oxidase (Rboh) Activity is Up Regulated during Sweet Pepper (Capsicum annuum L.) Fruit Ripening

Á Chu-Puga, S González-Gordo, M Rodríguez-Ruiz… - Antioxidants, 2019 - mdpi.com
In plants, NADPH oxidase (NOX) is also known as a respiratory burst oxidase homolog
(Rboh). This highly important enzyme, one of the main enzymatic sources of superoxide …

Carnosic acid inhibits reactive oxygen species-dependent neutrophil extracellular trap formation and ameliorates acute respiratory distress syndrome

YF Tsai, SC Yang, YH Hsu, CY Chen, PJ Chen, YT Syu… - Life Sciences, 2023 - Elsevier
Aims Infiltration of activated neutrophils into the lungs is a hallmark of acute respiratory
distress syndrome (ARDS). Neutrophilic inflammation, particularly neutrophil extracellular …

Nitric oxide: Regulation and function in neutrophil immune responses

S Kumar, M Dikshit - Antioxidants & Redox Signaling, 2024 - liebertpub.com
Significance: Neutrophils are crucial components of the innate immune system that combat
invading pathogens and maintain homeostasis. Nitric oxide (NO•) exerts regulatory …

Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin …

CC Chiang, WJ Cheng, CY Lin, KH Lai, SC Ju… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Kan-Lu-Hsiao-Tu-Tan (KLHTT) is a popular
traditional Chinese medicine for treating various inflammatory diseases. Aim of the study …

L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils

S Nagarkoti, S Sadaf, D Awasthi, T Chandra… - Free Radical …, 2019 - Taylor & Francis
Recent report from this lab has shown role of Rac2 in the translocation of inducible nitric
oxide synthase (iNOS) to the phagosomal compartment of polymorphonuclear leukocytes …

Self-sustained regulation or self-perpetuating dysregulation: ROS-dependent HIF-YAP-Notch signaling as a double-edged sword on stem cell physiology and …

CL Guo - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Organ development, homeostasis, and repair often rely on bidirectional, self-organized cell-
niche interactions, through which cells select cell fate, such as stem cell self-renewal and …