Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
Efficacy of CytoSorb®: a systematic review and meta-analysis
S Becker, H Lang, C Vollmer Barbosa, Z Tian, A Melk… - Critical Care, 2023 - Springer
Introduction Cytokine adsorption using the CytoSorb® adsorber has been proposed in
various clinical settings including sepsis, ARDS, hyperinflammatory syndromes, cardiac …
various clinical settings including sepsis, ARDS, hyperinflammatory syndromes, cardiac …
Cytokine hemoadsorption during cardiac surgery versus standard surgical care for infective endocarditis (REMOVE): results from a multicenter randomized controlled …
M Diab, T Lehmann, W Bothe, P Akhyari, S Platzer… - Circulation, 2022 - Am Heart Assoc
Background: Cardiac surgery often represents the only treatment option in patients with
infective endocarditis (IE). However, IE surgery may lead to a sudden release of …
infective endocarditis (IE). However, IE surgery may lead to a sudden release of …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
Prognostic and predictive enrichment in sepsis
NL Stanski, HR Wong - Nature Reviews Nephrology, 2020 - nature.com
Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …
Hemoadsorption with CytoSorb shows a decreased observed versus expected 28-day all-cause mortality in ICU patients with septic shock: a propensity-score …
WP Brouwer, S Duran, M Kuijper, C Ince - Critical Care, 2019 - Springer
Background and aims Innovative treatment modalities have not yet shown a clinical benefit
in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to …
in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to …
Vancomycin Resistance in Enterococcus and Staphylococcus aureus
Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …
commensals and major opportunistic human pathogens. In recent decades, these bacteria …
CytoSorb rescue for COVID-19 patients with vasoplegic shock and multiple organ failure: a prospective, open-label, randomized controlled pilot study
H Stockmann, P Thelen, F Stroben… - Critical care …, 2022 - journals.lww.com
OBJECTIVES: To investigate the effect of extracorporeal cytokine reduction by CytoSorb
(CytoSorbents, Monmouth Junction, NJ) on COVID-19–associated vasoplegic shock …
(CytoSorbents, Monmouth Junction, NJ) on COVID-19–associated vasoplegic shock …
Cytokine removal in human septic shock: Where are we and where are we going?
Although improving, the mortality from septic shock still remains high despite increased
international awareness. As a consequence, much effort has focused on alternative …
international awareness. As a consequence, much effort has focused on alternative …
Continuous renal replacement therapy with the addition of CytoSorb cartridge in critically ill patients with COVID‐19 plus acute kidney injury: a case‐series
A Alharthy, F Faqihi, ZA Memish, A Balhamar… - Artificial …, 2021 - Wiley Online Library
Our aim was to investigate continuous renal replacement therapy (CRRT) with CytoSorb
cartridge for patients with life‐threatening COVID‐19 plus acute kidney injury (AKI), sepsis …
cartridge for patients with life‐threatening COVID‐19 plus acute kidney injury (AKI), sepsis …