There have been magnificent advancements in the understanding of molecular mechanisms
of chronic diseases over the past several years, but these diseases continue to be a …

ABSTRACT Introduction: Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine-protein kinase,
an enzyme that in humans is encoded by the TYK2 gene. Tyk2, together with three other …

Numerous cytokines have been implicated in the pathogenesis of inflammatory diseases,
and their dysregulation is a main feature of rheumatoid arthritis (RA). Cytokines stimulate …

The current treatment approach in rheumatoid arthritis (RA) follows a stepwise management,
starting from early introduction of conventional synthetic (cs) disease-modifying anti …

Objective The aims of this study were to define the risk of serious bacterial infections in
patients receiving specific biological disease-modifying anti-rheumatic drugs (bDMARDs) …

Rheumatoid arthritis (RA) is a common autoimmune disease which impacts a large number
of patients worldwide, and new drugs are required for lower the disease burden. Theaflavin …

Spondyloarthritis (SpA) is the umbrella term for a broad spectrum of inflammatory rheumatic
diseases with typical but also rather different clinical manifestations, limited laboratory …

Gout is the most common form of inflammatory arthropathy, and is associated with
excruciating pain, major impairment of quality of life, and increased risk of comorbidities and …

Spondyloarthritis (SpA) is an inflammatory condition characterised by a broad spectrum of
clinical manifestations, laboratory abnormalities and imaging features that genetically tend …

Objective Obese patients with rheumatoid arthritis (RA) may be more likely to discontinue
therapy than non-obese patients, possibly signifying a more refractory phenotype. The …