Introduction The PI3K/Akt/mammalian target of rapamycin pathway is activated in a majority
of malignant pleural mesotheliomas (MPM). We evaluated the activity of everolimus, an oral …

The secretome is the complex set of molecules secreted by cells; these molecules play a key
role in cell signaling, communication and migration. Secretomics has been already used to …

Malignant mesothelioma (MMe) is a poor-prognosis tumor in need of innovative therapies. In
a previous in vivo study, we showed synergistic anti-MMe properties of the ascorbate …

Initiation is the rate-limiting phase of protein synthesis, controlled by signaling pathways
regulating the phosphorylation of translation factors. Initiation has three steps, 43S, 48S and …

Although asbestos is banned in several countries, malignant pleural mesothelioma (MPM)
incidence is increasing worldwide, and this cancer remains a disease of concern. MPM is a …

Simple Summary Malignant mesothelioma is a rare cancer arising from the serosal surfaces
of the body, mainly from the pleural layer. This cancer, strongly linked to asbestos exposure …

Despite recent dramatic advances in many solid tumors, malignant mesothelioma remains
challenging to treat. Historically, because of the modest number of cases globally and the …

Mass spectrometry (MS)-based methods have become popular in recent years for the
quantitation of biomolecules, especially peptides and proteins. High Mobility Group Box-1 …

EFFECTS OF DE NOVO PROTEIN SYNTHESIS ON CELL SPREADING, FORMATION OF
CELL-CELL CONTACTS, AND CO-LOCALIZATION OF PROTEINS AT CELL Page 1 …

Agradecimentos especiais a todos os meus amigos que tentaram me reconfortar quando as
coisas davam errado, que comemoraram comigo as minhas conquistas e que vez ou outra …