Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
Single-cell DNA methylation and 3D genome architecture in the human brain
Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …
understanding brain function in health and disease. Here, we comprehensively examined …
Interpreting non-coding disease-associated human variants using single-cell epigenomics
Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …
variants in the human genome to common traits and diseases. However, translating this …
Computational methods for analysing multiscale 3D genome organization
Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …
characterization of the spatial organization and folding of the genome in the nucleus. In …
[HTML][HTML] Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
CP D'Incal, KE Van Rossem, K De Man, A Konings… - Clinical …, 2023 - Springer
Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …
intellectual disability. The genes contributing to autism cluster on a relatively limited number …
scNanoHi-C: a single-cell long-read concatemer sequencing method to reveal high-order chromatin structures within individual cells
The high-order three-dimensional (3D) organization of regulatory genomic elements
provides a topological basis for gene regulation, but it remains unclear how multiple …
provides a topological basis for gene regulation, but it remains unclear how multiple …
The 3D genome structure of single cells
The spatial organization of the genome in the cell nucleus is pivotal to cell function.
However, how the 3D genome organization and its dynamics influence cellular phenotypes …
However, how the 3D genome organization and its dynamics influence cellular phenotypes …
[HTML][HTML] Genetic insights into immune mechanisms of Alzheimer's and Parkinson's disease
A Nott, IR Holtman - Frontiers in Immunology, 2023 - frontiersin.org
Microglia, the macrophages of the brain, are vital for brain homeostasis and have been
implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a …
implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a …
[HTML][HTML] Every gene everywhere all at once: High-precision measurement of 3D chromosome architecture with single-cell Hi-C
The three-dimensional (3D) structure of chromosomes influences essential biological
processes such as gene expression, genome replication, and DNA damage repair, and has …
processes such as gene expression, genome replication, and DNA damage repair, and has …