Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

In the wild, bacteria are predominantly associated with surfaces as opposed to existing as
free-swimming, isolated organisms. They are thus subject to surface-specific mechanics …

Bacteria have evolved a wide range of sensing systems to appropriately respond to
environmental signals. Here we demonstrate that the opportunistic pathogen Pseudomonas …

Background. Increasing antibiotic resistance warrants therapeutic alternatives. Here we
investigated the efficacy of bacteriophage-therapy (phage) alone or combined with …

Type IV pili (T4P) are one of the most common forms of bacterial and archaeal surface
structures, involved in adherence, motility, competence for DNA uptake, and pathogenesis …

SUMMARY Type IV pili (T4P) are multifunctional protein fibers produced on the surfaces of a
wide variety of bacteria and archaea. The major subunit of T4P is the type IV pilin, and …

▪ Abstract Twitching motility is a flagella-independent form of bacterial translocation over
moist surfaces. It occurs by the extension, tethering, and then retraction of polar type IV pili …

Polyphosphate kinase (PPK), encoded by the ppk gene, is the principal enzyme in many
bacteria for the synthesis of inorganic polyphosphate (poly P) from ATP. A knockout mutant …

The opportunistic human pathogen Pseudomonas aeruginosa effectively colonizes host
epithelia using pili as primary adhesins. Here we uncover a surface-specific asymmetric …

Twitching and social gliding motility allow many Gram negative bacteria to crawl along
surfaces, and are implicated in a wide range of biological functions. Type IV pili (Tfp) are …