Hepatic steatosis is a major etiological factor in hepatocellular carcinoma (HCC), but factors
causing lipid accumulation leading to HCC are not understood. We identify BNIP3 (a …

Lipid-related disorders, which primarily affect metabolic tissues, including adipose tissue
and the liver are associated with alterations in lysosome homeostasis. Obesity is one of the …

Lysosomal storage disorders (LSDs) are diseases characterized by the accumulation of
macromolecules in the late endocytic system and are caused by inherited defects in genes …

Abstract Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) based
lipidomics has become the most versatile analytical tool to discover and detect lipids using a …

Imaging of lipids of whole-body specimens in two-dimensional (2D) analysis provides a
global picture of the lipid changes in lipid-disturbed diseases, enabling a better …

Corticosteroids regulate vital processes, including stress responses, systemic metabolism,
and blood pressure. Here, we show that corticosteroid synthesis is related to the …

Lysosomes are the main degradative organelles of almost all eukaryotic cells. They fulfil a
crucial function in cellular homeostasis, and impairments in lysosomal function are …

Adequate homeostasis of lipid, protein and carbohydrate metabolism is essential for cells to
perform highly specific tasks in our organism, and the brain, with its uniquely high energetic …

Abstract Niemann-Pick C disease (NPC) is a lysosomal disease caused by mutations in
NPC1 or NPC2 genes responsible for intracellular accumulation of free cholesterol and …

Background Recent findings show that extracellular vesicle constituents can exert short-and
long-range biological effects on neighboring cells in the brain, opening an exciting avenue …