Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of neurological conditions
which have in common the progressive degeneration of upper and lower motor neurons …

Kinases are highly tractable drug targets that have reached unparalleled success in fields
such as cancer but whose potential has not yet been realized in neuroscience. There are …

Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic
heterogeneity. Machine learning approaches have previously been utilised for patient …

Telomere length (TL) is a biomarker of biological aging. Shorter telomeres have been
associated with mortality and increased rates of age-related diseases. However …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterized by the loss of upper and lower motor neurons, leading to progressive …

Aging is a gradual decline of physiological function and tissue homeostasis and, in many
instances, is related to increased (neuro)-degeneration, together with inflammation …

Since the discovery of Neural Stem Cells (NSCs) there are still mechanism to be clarified,
such as the role of mitochondrial metabolism in the regulation of endogenous adult …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease related to the
progressive death of motor neurons. Understanding the pathogenesis of ALS continues to …

While the precise mechanisms driving progressive forms of MS are not fully understood,
patient age has clear impact on disease phenotype. The very young with MS have high …

Amyotrophic lateral sclerosis is a neurodegenerative disease of the upper and lower motor
neurons resulting in death from neuromuscular respiratory failure, typically within two to five …