During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Background No large trials have been done to investigate the efficacy of an intervention
combining a specific compound and several lifestyle interventions compared with placebo …

Alzheimer's disease (AD) is characterized by two molecular pathologies: cerebral β-
amyloidosis in the form of β-amyloid (Aβ) plaques and tauopathy in the form of neurofibrillary …

In the past 8 years, both the International Working Group (IWG) and the US National Institute
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …

Objective To examine the independent and interactive influences of neuroimaging
biomarkers on retrospective cognitive decline. Methods A total of 152 middle-aged and older …

Background New research criteria for preclinical Alzheimer's disease have been proposed,
which include stages for cognitively normal individuals with abnormal amyloid markers …

Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease
(AD), but their topography and specific relationships with cognition remain unclear. Methods …

Objective: To determine the relationship between hearing loss and cognitive function as
assessed with a standardized neurocognitive battery. We hypothesized a priori that greater …

Objective: To test the hypothesis that MRI-based measurements of hippocampal volume are
related to the risk of future conversion to Alzheimer's disease (AD) in older patients with a …