Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND To provide the optimal milieu for implantation and fetal development, the
female reproductive system must orchestrate uterine dynamics with the appropriate …

STUDY QUESTION Can complete oocyte development be achieved from human ovarian
tissue containing primordial/unilaminar follicles and grown in vitro in a multi-step culture to …

As one of the problems and diseases for women before 40 years, premature ovarian failure
(POF) could be characterized by amenorrhea, low estrogen levels, infertility, high …

Enhanced long-term survival rates of young women with cancer and advances in
reproductive medicine and cryobiology have culminated in an increased interest in fertility …

STUDY QUESTION How does biochemical stimulation or inhibition of the PI3K/Akt/mTOR
pathway affect the activation and the growth of human primordial follicles in vitro …

Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

In vitro follicle growth is a potential approach to preserve fertility for young women who are
facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our …

Ovarian tissue cryopreservation is currently proposed to young cancer patients to preserve
their fertility before radiochemotherapy. The potential risk is that the tissue might harbor …

The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility
preservation option for young women. The only available option to restore fertility using this …