Virus particle dynamics derived from CryoEM studies
Highlights•CryoEM captures the dynamic character of the sample at the moment of
freezing.•A maximum likelihood algorithm determines the continuous variability of the …
freezing.•A maximum likelihood algorithm determines the continuous variability of the …
[HTML][HTML] Equilibrium dynamics of a biomolecular complex analyzed at single-amino acid resolution by cryo-electron microscopy
The biological function of macromolecular complexes depends not only on large-scale
transitions between conformations, but also on small-scale conformational fluctuations at …
transitions between conformations, but also on small-scale conformational fluctuations at …
Advances in tetravirus research: New insight into the infectious virus lifecycle and an expanding host range
RA Dorrington, M Jiwaji, JA Awando… - Current Issues in …, 2019 - mdpi.com
Tetraviruses are a group of relatively unknown small RNA viruses with particles that display
a characteristic T= 4 capsid architecture. Tetraviruses are classified into three families, the …
a characteristic T= 4 capsid architecture. Tetraviruses are classified into three families, the …
[PDF][PDF] Data to knowledge: how to get meaning from your result
Structural and functional studies require the development of sophisticatedBig
Data'technologies and software to increase the knowledge derived and ensure …
Data'technologies and software to increase the knowledge derived and ensure …
Effect of the viral protease on the dynamics of bacteriophage HK97 maturation intermediates characterized by variance analysis of cryo EM particle ensembles
Cryo EM structures of maturation-intermediate Prohead I of bacteriophage HK97 with (PhI
Pro+) and without (PhI Pro−) the viral protease packaged have been reported (Veesler et al …
Pro+) and without (PhI Pro−) the viral protease packaged have been reported (Veesler et al …
[HTML][HTML] Binding and entry of a non-enveloped T= 4 insect RNA virus is triggered by alkaline pH
DL Penkler, M Jiwaji, T Domitrovic, JR Short… - Virology, 2016 - Elsevier
Tetraviruses are small, non-enveloped, RNA viruses that exclusively infect lepidopteran
insects. Their particles comprise 240 copies of a single capsid protein precursor (CP), which …
insects. Their particles comprise 240 copies of a single capsid protein precursor (CP), which …
[HTML][HTML] Assembly and Maturation of a T = 4 Quasi-Equivalent Virus Is Guided by Electrostatic and Mechanical Forces
BM Kearney, JE Johnson - Viruses, 2014 - mdpi.com
Nudaurelia capensis ω virus (NωV) is a eukaryotic RNA virus that is well suited for the study
of virus maturation. The virus initially assembles at pH 7.6 into a marginally stable 480-Å …
of virus maturation. The virus initially assembles at pH 7.6 into a marginally stable 480-Å …
[HTML][HTML] An encapsidated viral protein and its role in RNA packaging by a non-enveloped animal RNA virus
A Mendes, M Vlok, JR Short, T Matsui, RA Dorrington - Virology, 2015 - Elsevier
Alphatetraviruses are small (+) ssRNA viruses with non-enveloped, icosahedral, T= 4
particles that assemble from 240 copies of a single capsid protein precursor. This study is …
particles that assemble from 240 copies of a single capsid protein precursor. This study is …
Allosteric effects in bacteriophage HK97 procapsids revealed directly from covariance analysis of cryo EM data
The information content of cryo EM data sets exceeds that of the electron scattering potential
(cryo EM) density initially derived for structure determination. Previously we demonstrated …
(cryo EM) density initially derived for structure determination. Previously we demonstrated …
Equilibrium Dynamics of a Biomolecular Complex Analyzed at Single-amino Acid Resolution by Cryo-electron Microscopy: Equilibrium Dynamics Revealed by cryo …
The biological function of macromolecular complexes depends not only on large-scale
transitions between conformations, but also on small-scale conformational fluctuations at …
transitions between conformations, but also on small-scale conformational fluctuations at …