Immunotherapy: reshape the tumor immune microenvironment

B Lv, Y Wang, D Ma, W Cheng, J Liu, T Yong… - Frontiers in …, 2022 - frontiersin.org
Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc.
The interactions between these components, which are divided into anti-tumor and pro …

Colorectal cancer immunotherapy: options and strategies

NA Johdi, NF Sukor - Frontiers in immunology, 2020 - frontiersin.org
Colorectal cancer is the third most common cancer in the world with increasing incidence
and mortality rates globally. Standard treatments for colorectal cancer have always been …

How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer

J Stultz, L Fong - Prostate cancer and prostatic diseases, 2021 - nature.com
Background Advanced prostate cancer remains one of the most common and deadly
cancers, despite advances in treatment options. Immunotherapy has provided little benefit to …

Dendritic cell–based cancer vaccines

PM Santos, LH Butterfield - The Journal of Immunology, 2018 - journals.aai.org
Dendritic cells (DC) are specialized immune cells that play a critical role in promoting an
immune response against Ags, which can include foreign pathogenic Ags and self-tumor …

The immune contexture in human tumours: impact on clinical outcome

WH Fridman, F Pagès, C Sautès-Fridman… - Nature Reviews …, 2012 - nature.com
Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels,
cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating …

Clinical use of dendritic cells for cancer therapy

S Anguille, EL Smits, E Lion, VF van Tendeloo… - The lancet …, 2014 - thelancet.com
Since the mid-1990s, dendritic cells have been used in clinical trials as cellular mediators for
therapeutic vaccination of patients with cancer. Dendritic cell-based immunotherapy is safe …

Dendritic cell–based immunotherapy: state of the art and beyond

KF Bol, G Schreibelt, WR Gerritsen, IJM De Vries… - Clinical cancer …, 2016 - AACR
Dendritic cell (DC) vaccination in cancer patients aims to induce or augment an effective
antitumor immune response against tumor antigens and was first explored in a clinical trial …

Roles of the immune system in cancer: from tumor initiation to metastatic progression

H Gonzalez, C Hagerling, Z Werb - Genes & development, 2018 - genesdev.cshlp.org
The presence of inflammatory immune cells in human tumors raises a fundamental question
in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor …

Immunotherapy of cancer in 2012

JM Kirkwood, LH Butterfield, AA Tarhini… - CA: a cancer journal …, 2012 - Wiley Online Library
The immunotherapy of cancer has made significant strides in the past few years due to
improved understanding of the underlying principles of tumor biology and immunology …

Dendritic cells as orchestrators of anticancer immunity and immunotherapy

I Heras-Murillo, I Adán-Barrientos, M Galán… - Nature Reviews …, 2024 - nature.com
Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …