The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Esophageal cancer (EC) is one of the most common cancers with high morbidity and
mortality rates. EC includes two histological subtypes, namely esophageal squamous cell …

The epidermal growth factor receptor (EGFR) belongs to the tyrosine kinase receptors family
and is present in the epithelial cell membrane. Its endogenous activation occurs through the …

Context Leucovorin, fluorouracil, and oxaliplatin (FOLFOX) is the standard adjuvant therapy
for resected stage III colon cancer. Adding cetuximab to FOLFOX benefits patients with …

Disease mechanisms are increasingly being resolved at the molecular level. Biomedical
success at this scale creates synthetic opportunities for combining specifically designed …

There is considerable interest in the use of bioorthogonal covalent chemistry such as “click”
chemistries to label small molecules located on live or fixed cells.[1] Such labeling has been …

As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a
polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and …

A subset of human papillomavirus (HPV) infections is causally related to the development of
human epithelial tumors and cancers. Like a number of pathogens, HPV entry into target …

Colorectal cancer is the second most common cancer, representing 13% of all diagnosed
cancers. Cetuximab is a recombinant chimeric monoclonal IgG1 antibody and epidermal …

Squamous cell carcinoma (SCC) is a malignant tumor in which epidermal growth factor
receptor (EGFR) overexpression is associated with poor prognosis and malignancy. For …