Non-human primates play a key role in the preclinical validation of pluripotent stem cell-
based cell replacement therapies. Pluripotent stem cells used as advanced therapy medical …

The experimental production of complex structures resembling mammalian embryos (eg,
blastoids, gastruloids) from pluripotent stem cells in vitro has become a booming research …

The establishment of cellular identity is driven by transcriptional and epigenetic regulators of
the chromatin proteome-the chromatome. Comprehensive analyses of the chromatome …

Evolutionary innovations can be driven by changes in the rates of RNA translation and the
emergence of new genes and small open reading frames (sORFs). In this study, we …

Comparing the molecular and cellular properties among primates is crucial to better
understand human evolution and biology. However, it is difficult or ethically impossible to …

Non-human primates (NHPs) are, due to their close phylogenetic relationship to humans,
excellent animal models to study clinically relevant mutations. However, the toolbox for the …

Cardiomyocytes can be implanted to remuscularize the failing heart,,,,,–. Challenges include
sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable …

The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been
implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its …

Macrophages are important target cells for diverse viruses and thus represent a valuable
system for studying virus biology. Isolation of primary human macrophages is done by …

The cerebral cortex is the outermost brain structure and is responsible for the processing of
sensory input and motor output; it is seen as the seat of higher-order cognitive abilities in …