Lipotoxicity and β-cell failure in type 2 diabetes: Oxidative stress linked to NADPH oxidase and ER stress

EA Vilas-Boas, DC Almeida, LP Roma, F Ortis… - Cells, 2021 - mdpi.com
A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

NADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humans

AW Segal - Open biology, 2016 - royalsocietypublishing.org
The NOXs are a family of flavocytochromes whose basic structure has been largely
conserved from algae to man. This is a very simple system. NADPH is generally available, in …

Chloride flux in phagocytes

G Wang - Immunological reviews, 2016 - Wiley Online Library
Phagocytes, such as neutrophils and macrophages, engulf microbes into phagosomes and
launch chemical attacks to kill and degrade them. Such a critical innate immune function …

Targeting TRPM2 in ROS-coupled diseases

S Yamamoto, S Shimizu - Pharmaceuticals, 2016 - mdpi.com
Under pathological conditions such as inflammation and ischemia-reperfusion injury large
amounts of reactive oxygen species (ROS) are generated which, in return, contribute to the …

Cnidaria: anthozoans in the hot seat

CV Palmer, NG Traylor-Knowles - Advances in comparative immunology, 2018 - Springer
Cnidarians comprise a diverse and phylogenetically basal phylum, some of which—such as
scleractinian corals (Anthozoa)—are responsible for the formation and maintenance of …

A brief history of oxygen: 250 years on

JT Hancock - Oxygen, 2022 - mdpi.com
Although there has been some controversy surrounding exactly when oxygen was first
discovered, it is likely that that accolade should go to Carl Wilhelm Scheele, who isolated …

Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans

WK Bessler, FZ Hudson, H Zhang, V Harris… - Free Radical Biology …, 2016 - Elsevier
Abstract Neurofibromatosis type 1 (NF1) predisposes individuals to early and debilitating
cardiovascular disease. Loss of function mutations in the NF1 tumor suppressor gene, which …

Revisiting staining of biological samples for electron microscopy: perspectives for recent research

MT Kuchenbrod, US Schubert, R Heintzmann… - Materials …, 2021 - pubs.rsc.org
This review revisits essential staining protocols for electron microscopy focussing on the
visualization of active sites, ie enzymes, metabolites or proteins, in cells and tissues, which …

In memoriam: Filippo Rossi (1926–2022) The scientist who got it right-NADPH (not NADH) oxidase

E Pick - Journal of Leukocyte Biology, 2023 - academic.oup.com
In memoriam: Filippo Rossi (1926–2022) | Journal of Leukocyte Biology | Oxford Academic Skip
to Main Content Advertisement Oxford Academic Journals Books Search Menu Information …

[PDF][PDF] Neutrophils and their friends

MA Cassatella, WM Nauseef - Immunological Reviews, 2023 - iris.univr.it
2| INTRO DUC TIO N to train health care professionals and participated in the humanitarian
activities of Amahoro Proafrica in Burundi (Figure 1b). In the final years of his academic …