Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid

N Esfandiari, N Saadati Ardestani, RS Alwi, A Rojas… - Scientific Reports, 2023 - nature.com
A static method is employed to determine the solubilities of verapamil in supercritical carbon
dioxide (SC-CO2) at temperatures between 308 and 338 K and pressures between 12 and …

Solubility of Lacosamide in supercritical carbon Dioxide: An experimental analysis and thermodynamic modeling

N Esfandiari, SA Sajadian - Journal of Molecular Liquids, 2022 - Elsevier
Lacosamide has been used to control partial-onset seizures (seizures that involve only one
part of the brain) in adults and children. In this article, Lacosamide solubility in the SC-CO 2 …

Investigation on co-solvency, solvent effect, Hansen solubility parameter and preferential solvation of fenbufen dissolution and models correlation

Y Cong, C Du, K Xing, Y Bian, X Li, M Wang - Journal of Molecular Liquids, 2022 - Elsevier
The solubility behavior as a significant molecular property in pharmaceuticals development
is challenging in modern pharmaceutical industry. The high quality solubility is …

Research on dissolution of actarit in aqueous mixtures: Solubility determination and correlation, preferential solvation, solvent effect and thermodynamics

Y Cong, C Du, K Xing, Y Bian, X Li, M Wang - Journal of Molecular Liquids, 2022 - Elsevier
The solubility information and dissolution mechanism of drugs in mixtures is significant in
chemistry and pharmaceutical domains. The equilibrium saturated solubility of actarit in …

Synergistic solvation effect and modeling of itraconazole solubility in eight binary mixtures (dichloromethane and chloroform+ primary alcohol) at the range of 288.15 K …

SK Lee, ES Ha, H Park, JS Jeong, JS Kim… - The Journal of Chemical …, 2023 - Elsevier
In this study, the solubility and apparent thermodynamic parameters of itraconazole in
chlorinated methane (dichloromethane and chloroform)+ primary alcohol (methanol …

Solubility determination, Hansen solubility parameter, solvent effect and preferential solvation of thenalidine in four aqueous binary mixtures

R Xu, G Yao - Journal of Molecular Liquids, 2023 - Elsevier
The equilibrium solubility of thenalidine in four solvent mixtures (ethanol+ water, n-
propanol+ water, isopropanol+ water, and N, N-dimethylformamide (DMF)+ water) was …

Thermodynamic solubility determination of khellin in eight mono-solvents at the range of 298.15 to 323.15 K

RP Shah, SS Bharate - Journal of Molecular Liquids, 2022 - Elsevier
Khellin is a medicinally important furanocoumarin class of natural product. It has led to the
discovery of two first-in-class drugs, which embarks the potential of the scaffold for future …

Estimating thermodynamic equilibrium solubility and solute–solvent interactions of niclosamide in eight mono-solvents at different temperatures

JS Bhanushali, SS Bharate - Journal of Molecular Liquids, 2022 - Elsevier
Niclosamide is an FDA-approved oral anthelmintic drug currently being repurposed for
COVID-19 infection. Its interesting applicability in multiple therapeutic indications has …

[HTML][HTML] Investigation and assessment of equilibrium solubility, Hansen solubility parameters and modeling of natural plant medicine artemisinin (Form Ⅰ) in three …

P Zhang, B Wu, H Sun, H Luo, R Feng, C Jin… - Industrial Crops and …, 2025 - Elsevier
Artemisinin has been widely used in various countries around the world for the treatment of
malaria, which has saved so many lives that it continues to attract the attention of scientific …

[HTML][HTML] Experimental and Model-Based Approach to Evaluate Solvent Effects on the Solubility of the Pharmaceutical Artemisinin

S Wünsche, V Tenberg, K Oliynyk… - European Journal of …, 2024 - Elsevier
The separation and purification of plant-based Active Pharmaceutical Ingredients (API) from
extracts is a crucial part in pharmaceutical process development. For the purification of the …