Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …

Emerging pharmaceutical therapies for osteoarthritis

A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

[HTML][HTML] Osteoarthritis year in review 2019: epidemiology and therapy

M Kloppenburg, F Berenbaum - Osteoarthritis and cartilage, 2020 - Elsevier
Over the past year many studies and clinical trials have been published in the osteoarthritis
(OA) field. This review is based on systematic literature review covering the period May 1 st …

Chondrocyte dedifferentiation and osteoarthritis (OA)

E Charlier, C Deroyer, F Ciregia, O Malaise… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

[HTML][HTML] Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

CR Harrell, BS Markovic, C Fellabaum… - Biomedicine & …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …

Exosomes: roles and therapeutic potential in osteoarthritis

Z Ni, S Zhou, S Li, L Kuang, H Chen, X Luo, J Ouyang… - Bone research, 2020 - nature.com
Exosomes participate in many physiological and pathological processes by regulating cell–
cell communication, which are involved in numerous diseases, including osteoarthritis (OA) …

Repair of damaged articular cartilage: current approaches and future directions

EV Medvedeva, EA Grebenik, SN Gornostaeva… - International journal of …, 2018 - mdpi.com
Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial

N Gerwin, C Scotti, C Halleux, M Fornaro, J Elliott… - Nature Medicine, 2022 - nature.com
Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying
drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 …