A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …

The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide
gene. Achieving the same using small molecules would have a tremendous impact on …

Large-scale genomic studies have identified multiple somatic aberrations in breast cancer,
including copy number alterations and point mutations. Still, identifying causal variants and …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

New neurons and glial cells are generated in an extensive germinal niche adjacent to the
walls of the lateral ventricles in the adult brain. The primary progenitors (B1 cells) have …

HNRNPU encodes the heterogeneous nuclear ribonucleoprotein U, which participates in
RNA splicing and chromatin organization. Microdeletions in the 1q44 locus encompassing …

Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …

Adult neurogenesis is an exceptional feature of the adult brain and in an intriguing way
bridges between neuronal and glial neurobiology. Essentially, all classes of glial cells are …

Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural
development and tumorigenesis,. Besides its classic morphogenic activity, Shh is also a …