The striatum, a major component of the basal ganglia, performs multiple functions including
control of movement, reward, and addiction. Dysfunction and death of striatal neurons are …

Early in development of the central nervous system, radial glial cells arise from the
neuroepithelial cells lining the ventricles around the time that neurons begin to appear. The …

Human telencephalon is an evolutionarily advanced brain structure associated with many
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …

The precursor function of the ubiquitous glial cell type in the developing central nervous
system (CNS), the radial glia, is largely unknown. Using Cre/loxP in vivo fate mapping …

Recent studies suggest that neurons born in the developing basal forebrain migrate long
distances perpendicularly to radial glia and that many of these cells reach the developing …

During development, the mammalian ventral telencephalon is comprised of three major
proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic …

The striatum, the largest component of the basal ganglia, contains projection neurons and
interneurons. Whereas there is considerable agreement that the lateral ganglionic eminence …

The lateral ganglionic eminence (LGE) is known to give rise to striatal projection neurons as
well as interneurons, which migrate in the rostral migratory stream (RMS) to populate the …

The directed differentiation of forebrain neuronal types from human embryonic stem cells
(hESCs) has not been achieved. Here, we show that hESCs differentiate to telencephalic …

The mechanisms governing the expansion of neuron number in specific brain regions are
still poorly understood. Enlarged neuron numbers in different species are often anticipated …