Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite
recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the …

Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate
decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

Background Autophagy is a dynamic physiological process that can generate energy and
nutrients for cell survival during stress. Autophagy can regulate the migration and invasive …

Diabetes is closely related to the occurrence of endometrial cancer (EC) and its poor
prognosis. However, there is no effective clinical treatment for EC patients with diabetes …

Abstract Machine learning is an established data interpretation tool for the development of
processing, extracting and extrapolating evocative results from complex data sets. Data …

The highly conserved Wnt signalling pathway plays an important role in embryonic
development and disease pathogenesis, most notably cancer. The 'canonical'or β‐catenin …

Colorectal cancer (CRC) is a heterogeneous group of diseases that are the result of
abnormal glucose metabolism alterations with high lactate production by pyruvate to lactate …

The mRNA life cycle is a complex biochemical process, involving transcription initiation,
elongation, termination, splicing, and degradation. Each of these molecular events is …

Quantitative characterization of the tumor microenvironment, including its immuno-
architecture, is important for developing quantitative diagnostic and predictive biomarkers …