Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …

Newly diagnosed glioblastoma is now commonly treated with surgery, if feasible, or biopsy,
followed by radiation plus concomitant and adjuvant temozolomide. The treatment of …

Using MRI techniques, we show here that normalization of tumor vessels in recurrent
glioblastoma patients by daily administration of AZD2171—an oral tyrosine kinase inhibitor …

Purpose The prognosis for patients with recurrent glioblastoma multiforme is poor, with a
median survival of 3 to 6 months. We performed a phase II trial of bevacizumab, a …

Introduction Standards of care are not yet defined in recurrent glioblastoma. Methods We
reviewed the literature on clinical trials for recurrent glioblastoma available in PubMed and …

Cancer is a heterogeneous disease, which provides a broad field for investigation, while
simultaneously reducing the chances for a universal treatment. Malignant gliomas are the …

Learning Objectives After completing this course, the reader will be able to: List the different
major subtypes of glioma and identify the appropriate treatment strategies for patients with …

Learning Objectives After completing this course, the reader will be able to: Describe the
genetic alterations frequently observed in GBM tumors as well as the cell signal transduction …

Background The prognosis for recurrent/progressive Ewing sarcoma (ES) remains poor. Pre‐
clinical, adult phase I and II trials have demonstrated the combination of irinotecan and …

High-grade astrocytomas include the most common adult central nervous system (CNS)
tumor, glioblastoma multiforme, and anaplastic astrocytoma—a highly aggressive cancer …