Familial hypercholesterolemia and elevated lipoprotein (a): double heritable risk and new therapeutic opportunities

A Vuorio, GF Watts, WJ Schneider… - Journal of internal …, 2020 - Wiley Online Library
There is compelling evidence that the elevated plasma lipoprotein (a)[Lp (a)] levels increase
the risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. Like …

[HTML][HTML] Review of serum biomarkers in carotid atherosclerosis

E Martinez, J Martorell, V Riambau - Journal of Vascular Surgery, 2020 - Elsevier
Background Carotid artery atherosclerotic stenosis is a preventable major cause of stroke,
but there is still a need for definition of high-risk plaque in asymptomatic patients who might …

Lipoprotein apheresis: current recommendations for treating familial hypercholesterolemia and elevated lipoprotein (a)

MS Safarova, PM Moriarty - Current Atherosclerosis Reports, 2023 - Springer
Abstract Purpose of Review Familial hypercholesterolemia (FH) and hyperlipoproteinemia
(a) are relatively common disorders, posing a significant health burden due to increased risk …

[HTML][HTML] Modern approaches to lower lipoprotein (a) concentrations and consequences for cardiovascular diseases

VA Korneva, TY Kuznetsova, U Julius - Biomedicines, 2021 - mdpi.com
Lipoprotein (a)(Lp (a)) is a low density lipoprotein particle that is associated with poor
cardiovascular prognosis due to pro-atherogenic, pro-thrombotic, pro-inflammatory and pro …

The renaissance of lipoprotein (a): brave new world for preventive cardiology?

KL Ellis, MB Boffa, A Sahebkar, ML Koschinsky… - Progress in Lipid …, 2017 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a highly heritable cardiovascular risk factor. Although
discovered more than 50 years ago, Lp (a) has recently re-emerged as a major focus in the …

[HTML][HTML] Impact of ezetimibe on plasma lipoprotein (a) concentrations as monotherapy or in combination with statins: a systematic review and meta-analysis of …

A Sahebkar, LE Simental-Mendía, M Pirro… - Scientific Reports, 2018 - nature.com
The aim of this meta-analysis of randomized placebo-controlled clinical trials was to assess
the effect of ezetimibe on plasma lipoprotein (a) concentrations. Only randomized placebo …

Supplementation with coenzyme Q10 reduces plasma lipoprotein (a) concentrations but not other lipid indices: a systematic review and meta-analysis

A Sahebkar, LE Simental-Mendía, C Stefanutti… - Pharmacological …, 2016 - Elsevier
Abstract Plasma lipoprotein (a)[Lp (a)] elevations are associated with increased
cardiovascular risk. Coenzyme Q 10 (CoQ 10) is a member of the mitochondrial respiratory …

Selenium and vitamin B6 cosupplementation improves dyslipidemia and fatty liver syndrome by SIRT1/SREBP-1c pathway in hyperlipidemic Sprague-Dawley rats …

Q Zhang, X Zhou, J Zhang, Q Li, Z Qian - Nutrition Research, 2022 - Elsevier
Previously, our group found that the dietary trace mineral element selenium and vitamin B 6
(VitB 6) alone was involved in lipid metabolism. However, the effects of selenium combined …

Specific Lp (a) apheresis: A tool to prove lipoprotein (a) atherogenicity

SN Pokrovsky, OI Afanasieva, MS Safarova… - Atherosclerosis …, 2017 - Elsevier
Background An elevated lipoprotein (a)(Lp (a)) level is observed in more than 30% of
patients with stable ischemic heart disease (SIHD). We conducted an investigation of the …

[HTML][HTML] Therapeutic management of hyperlipoproteinemia (a)

CE Kosmas, A Sourlas, G Mallarkey, D Silverio… - Drugs in …, 2019 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) has consistently been the leading cause of death worldwide.
Several clinical and epidemiological studies have demonstrated that an elevated plasma …