Essential proteins and possible therapeutic targets of Wolbachia endosymbiont and development of FiloBase-a comprehensive drug target database for Lymphatic …

OP Sharma, MS Kumar - Scientific Reports, 2016 - nature.com
Lymphatic filariasis (Lf) is one of the oldest and most debilitating tropical diseases. Millions
of people are suffering from this prevalent disease. It is estimated to infect over 120 million …

Identification of dual active sites in Caenorhabditis elegans GANA-1 protein: an ortholog of the human α-GAL a and α-NAGA enzymes

CSY Cheong, SU Khan, N Ahmed… - Journal of Biomolecular …, 2023 - Taylor & Francis
Fabry disease (FD) is caused by a defective α-galactosidase A (α-GAL A) enzyme
responsible for breaking down globotriaosylceramide (Gb3). To develop affordable …

[PDF][PDF] The olig family member HLH-17 controls animal behavior by modulating neurotransmitter signaling in caenorhabditis elegans

C Felton - 2014 - scholarworks.gsu.edu
In vertebrate and invertebrate systems, the role of glia-neuron interactions during
development and behavior is becoming apparent. Recent studies have been aimed at …

Probing the Structural and Conformational Stability of the Wb-iPGM Enzyme and Role of Mn2+ Ions in Their Catalytic Site

OP Sharma, K Hari Krishna… - International Journal of …, 2015 - Springer
Cofactor-independent phosphoglycerate mutase (iPGM) is an indispensable enzyme for
most of the nematodes including filarial nematodes. Therefore could be targeted as a vital …