Garlic is widely accepted as a functional food and an excellent source of pharmacologically
active ingredients. Diallyl disulfide (DADS), a major bioactive component of garlic, has …

Alliums and allied plant species are rich sources of sulfur compounds that have effects on
vascular homeostasis and the control of metabolic systems linked to nutrient metabolism in …

Tramadol, a frequently used pain reliever drug, present neurotoxic effects associated to
cognitive dysfunction. Moreover, crocin has been reported to have neuroprotective effects …

Abstract β‐caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective
agonist of cannabinoid receptor type‐2 (CB2) of the endocannabinoid system. In this study …

Carbazole based novel multifunctional agents has been rationally designed and
synthesized as potential anti-Alzheimer agents. Multi-functional activity of these derivatives …

Background Mild cognitive impairment (MCI) is a typical symptom of early Alzheimer's
disease (AD) and is driven by the dysfunction of microRNAs (miRs). Repetitive transcranial …

Microglia are the innate immune cells in the nervous system. In the resting state, they display
a ramified morphology, while upon disease stimulation their processes would be retracted …

Background Microtubule formation is a dynamic process and Tau proteins promote the
assembly of tubulin monomers into microtubules. Hyperphosphorylation of some amino …

ABSTRACT Objective: JM-20, a novel hybrid synthetic molecule, has been reported to have
antioxidant, mitoprotective, anti-excitotoxic, anti-apoptotic and anti-inflammatory properties …

Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by memory
loss and cognitive decline. With current treatments offering limited effectiveness, researchers …