Molecular beacons (MBs) have been used as viable fluorescent probes in nucleic acid
analysis. Many researchers around the world continue to modify the MBs to suit their needs …

Increasing evidence has suggested that single-nucleotide polymorphisms (SNPs) are
closely associated with medical conditions and genetic diseases, although the majority has …

Precisely localizing therapeutic agents in neoplastic areas would greatly improve their
efficacy for killing tumor cells and reduce their toxicity to normal cells. Photodynamic therapy …

Abstract RNA 可与各种核酸及蛋白质相互作用, 在多种生理和病理过程中发挥重要的调控作用,
其生物学过程高度动态. 追踪活细胞中的 RNA 动态对理解基因表达的时空调控以及 RNA …

Antisense oligonucleotides and short interfering RNAs are widely used for sequence‐
specific silencing of gene expression. More widespread acceptance and adoption of these …

Abstract RNA 可与各种核酸及蛋白质相互作用， 在多种生理和病理过程中发挥重要的调控作用
， 其生物学过程高度动态。 追踪活细胞中的RNA 动态对理解基因表达的时空调控以及RNA …

There is a growing realization that cell-to-cell variations in gene expression have important
biological consequences underlying phenotype diversity and cell fate. Although analytical …

Nukleinsäuretemplatkontrollierte Reaktionen, die häufig auf Ligations-oder
Transferreaktionen basieren, unterliegen dem Effekt der Produktinhibierung. Dadurch …

Many algorithms based on computational analysis and thermodynamic parameters have
been developed to predict the secondary structure of RNA. Still, many antisense …

We developed self-quenching reporter molecules (SQRMs), oligodeoxynucleotides with
fluorophore and quencher moieties at the 5′ and 3′ ends respectively, to probe mRNAs …