Responding to tissue injury, skeletal muscles undergo the tissue destruction and
reconstruction accompanied with inflammation. The immune system recognizes the …

The skeletal muscle is a dynamic organ composed of contractile muscle fibers, connective
tissues, blood vessels and nerve endings. Its main function is to provide motility to the body …

Aging is associated with profound alterations in skeletal muscle, including loss of muscle
mass and function, local inflammation, altered mitochondrial physiology, and attenuated …

Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages
which respond to an initial inflammatory insult common in all forms of fibrosis. The recently …

Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or
through self-renewal. While the presence of a nurturing niche is likely crucial to support the …

Periodontal disease is a chronic inflammatory condition that results in the destruction of the
teeth supporting tissues, eventually leading to the loss of teeth and reduced quality of life. In …

Inflammaging, a pro-inflammatory status that characterizes aging and primarily involving
macrophages, is a master driver of age-related diseases. Mineralocorticoid receptor (MR) …

Insulin resistance is a crucial factor in the development of type 2 diabetes mellitus (T2DM)
and other metabolic disorders. Skeletal muscle, the body's largest insulin-responsive tissue …

Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

Satellite cells are bona fide muscle stem cells that are indispensable for successful post-
natal muscle growth and regeneration after severe injury. These cells also participate in …