Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …

Tumor progression relies on the ability of cancer cells to effectively invade surrounding
tissues and propagate. Among the many mechanisms that contribute to tumor progression is …

Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …

Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …

Therapy resistance is a major problem when treating cancer patients as cancer cells
develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and …

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …

Simple Summary Despite the adoption of aggressive, multimodal treatment schedules, the
cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 …

The tumor stroma of pancreatic ductal adenocarcinoma (PDAC) is characterized by an
abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are …

Abstract Ethnopharmacological relevance Huaier (Trametes robiniophila Murr), a traditional
Chinese medicinal fungus, possesses potent anticancer efficacy and has been used as an …

Docetaxel (Doc) is a cornerstone of chemotherapy; however, treatment with Doc often and
inevitably leads to drug resistance and the formation of polyploid giant cancer cells …