Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

The cytoskeleton is an interconnected network that provides support and organization to
cells. In eukaryotes, its main components include actin and microtubules, two types of …

Mechanotransduction, the transformation of mechanical force into an electrical signal, allows
living organisms to hear, register movement and gravity, detect touch, and sense changes in …

Identifying targets of positive selection in humans has, until recently, been frustratingly slow,
relying on the analysis of individual candidate genes. Genomics, however, has provided the …

Mammals have an astonishing ability to sense and discriminate sounds of different
frequencies and intensities. Fundamental for this process are mechanosensory hair cells in …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

The myosin family of actin filament-based molecular motors consists of at least 20
structurally and functionally distinct classes. The human genome contains nearly 40 myosin …

Inner hair cells (IHCs) and outer hair cells (OHCs) are the two types of sensory receptor cells
that are critical for hearing in the mammalian cochlea. IHCs and OHCs have different …

Background Sexual dimorphism results in the formation of two types of individuals with
specialized reproductive roles and is most evident in the germ cells and gonads. Results We …