[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

An Update on Zoonotic Cryptosporidium Species and Genotypes in Humans

U Ryan, A Zahedi, Y Feng, L Xiao - Animals, 2021 - mdpi.com
Simple Summary Cryptosporidium is a parasite that infects humans and a broad range of
animals. There are few diagnostic features that can be used to identify and differentiate …

Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases

G Ianiro, M Punčochář, N Karcher, S Porcari… - Nature Medicine, 2022 - nature.com
Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides
difficile infection and is considered a promising treatment for other microbiome-related …

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

KA Lee, AM Thomas, LA Bolte, JR Björk… - Nature Medicine, 2022 - nature.com
The composition of the gut microbiome has been associated with clinical responses to
immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific …

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

F Asnicar, SE Berry, AM Valdes, LH Nguyen… - Nature medicine, 2021 - nature.com
The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

Extensive unexplored human microbiome diversity revealed by over 150,000 genomes from metagenomes spanning age, geography, and lifestyle

E Pasolli, F Asnicar, S Manara, M Zolfo, N Karcher… - Cell, 2019 - cell.com
The body-wide human microbiome plays a role in health, but its full diversity remains
uncharacterized, particularly outside of the gut and in international populations. We …

Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes

Z Mei, F Wang, A Bhosle, D Dong, R Mehta, A Ghazi… - Nature medicine, 2024 - nature.com
The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent
due in part to the complexity of this disease and variation in study design. Even in cases in …

The global human gut microbiome: genes, lifestyles, and diet

M Parizadeh, MC Arrieta - Trends in Molecular Medicine, 2023 - cell.com
A growing number of human gut microbiome studies consistently describe differences
between human populations. Here, we review how factors related to host genetics, ethnicity …

Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

E Piperni, LH Nguyen, P Manghi, H Kim, E Pasolli… - Cell, 2024 - cell.com
Diet impacts human health, influencing body adiposity and the risk of developing
cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but …

Microbiome epidemiology and association studies in human health

H VanEvery, EA Franzosa, LH Nguyen… - Nature Reviews …, 2023 - nature.com
Studies of the human microbiome share both technical and conceptual similarities with
genome-wide association studies and genetic epidemiology. However, the microbiome has …