Background: The time variation between consecutive heartbeats is commonly referred to as
heart rate variability (HRV). Loss of complexity in HRV has been documented in several …

Chronic fetal hypoxia and infection are examples of adverse conditions during complicated
pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease …

Sinoatrial nodal cells (SANCs) generate spontaneous action potentials (APs) that control the
cardiac rate. The brain modulates SANC automaticity, via the autonomic nervous system, by …

Cardiovascular function is regulated by the rhythmicity of circadian, infradian and ultradian
clocks. Specific time scales of different cell types drive their functions: circadian gene …

Introduction Ca2+ release from sarcoplasmic reticulum (SR) is known to contribute to
automaticity via the cytoplasmic Na+-Ca2+ exchanger (NCX). Mitochondria participate in …

Spontaneous firing of sinoatrial (SA) node cells (SANCs) is regulated by cyclic adenosine
monophosphate (cAMP)-mediated, protein kinase A (PKA)-dependent (cAMP/PKA) local …

Methods: The response of HR to vagus nerve stimulation was tested after bilateral vagotomy
in rabbits under anesthesia. Three protocols were followed: 1. Single burst stimulation at …

Sinoatrial node (SAN) is the pacemaker of the heart in charge of initiating spontaneous
electronical activity and controlling heart rate. Myocytes from SAN can generate …

Automaticity involves Ca2+ handling at the cell membrane and sarcoplasmic reticulum (SR).
Abnormal or acquired automaticity is thought to initiate ventricular arrhythmias associated …

The PhysioZoo database contains electrocardiographic recordings (ECG) taken from
multiple types of mammals (dogs, rabbits, mice). Each record is provided in 3 different …