Endpoints of large‐scale trials in chronic heart failure have mostly been defined to evaluate
treatments with regard to hospitalizations and mortality. However, patients with heart failure …

Skeletal muscle contractile function declines with aging, disease, and disuse. In vivo muscle
contractile function depends on a variety of factors, but force, contractile velocity and power …

Background—Skeletal muscle strength, velocity, and power are markedly reduced in
patients with heart failure, which contributes to their impaired exercise capacity and lower …

We hypothesize that age-related skeletal muscle dysfunction and physical disability may be
partially explained by alterations in the function of the myosin molecule. To test this …

Purpose Patients with chronic heart failure (CHF) report difficulty performing activities of
daily living. To our knowledge, however, no study has directly measured performance in …

Skeletal muscle contractile performance is governed by the properties of its constituent
fibers, which are, in turn, determined by the molecular interactions of the myofilament …

Age-related loss of skeletal muscle mass and function is implicated in the development of
disease and physical disability. However, little is known about how age affects skeletal …

Physiologic endurance exercise performance is primarily limited by cardiac function. In
patients with heart failure, there is dissociation between cardiac performance and exercise …

Nas doenças crônicas, como câncer e insuficiência cardíaca (IC), a fadiga é um sintoma
comum e complexo do ponto de vista etiológico e fisiopatológico, portanto, um tema de …

Key points Heart failure is characterised by limb and respiratory muscle impairments that
limit functional capacity and quality of life. However, compared with heart failure with …