[图书][B] Die fehlenden Unternehmer Politiken für ein integrationsförderndes Unternehmertum in Europa: Politiken für ein integrationsförderndes Unternehmertum in …

The European Commission - 2014 - books.google.com
Entwicklung von Unternehmertum ist eine wichtige Voraussetzung für die Verwirklichung
eines intelligenten, nachhaltigen und integrativen Wachstums. Es ist auch ein Mittel, um auf …

Hyperactivity and spatial maze learning impairment of adult rats with temporary neonatal hypothyroidism

M Akaike, N Kato, H Ohno, T Kobayashi - Neurotoxicology and teratology, 1991 - Elsevier
Temporary hypothyroidism was induced in neonatal rats by 0.02% propylthiouracil (PTU)
administration to lactating dams during days 0–19 after delivery, and its effects on the …

Trimethyltin syndrome as a hippocampal degeneration model: temporal changes and neurochemical features of seizure susceptibility and learning impairment

N Ishida, M Akaike, S Tsutsumi, H Kanai, A Masui… - Neuroscience, 1997 - Elsevier
The effects of trimethyltin on the hippocampus were investigated in terms of changes in
histology, depth electroencephalography, learning acquisition and memory retention …

Differential effects between developmental and postpubertal exposure to N-methyl-N-nitrosourea on progenitor cell proliferation of rat hippocampal neurogenesis in …

Y Watanabe, K Nakajima, S Mizukami, Y Akahori… - Toxicology, 2017 - Elsevier
This study was performed to compare the exposure effects of N-methyl-N-nitrosourea
(MNU), a cytocidal agent of proliferating cells, on rat hippocampal neurogenesis between …

Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen

J Hoover-Plow, O Skomorovska-Prokvolit, S Welsh - Brain research, 2001 - Elsevier
In vitro studies demonstrate a role for the plasminogen (Plg) system in neurological function
and recently in vivo studies show a role of the Plg system in neurodegeneration after the …

Comparison of four spatial maze learning tests with methylnitrosourea‐induced microcephaly rats

M Akaike, H Ohno, S Tsutsumi, M Omosu - Teratology, 1994 - Wiley Online Library
The usefulness of four spatial maze learning test methods, single T‐maze, Biel water maze,
Morris water maze, and radial eightarm maze, was compared using rats with different …

Behavioral characteristics of micrencephalic rats in high and low shuttlebox avoidance lines

R Ohta, A Matsumoto, Y Hashimoto, T Nagao… - Neurotoxicology and …, 1997 - Elsevier
Rats of two lines, selectively bred for high and low shuttlebox avoidance response, and
unselected line of the Sprague-Dawley (SD) rats were given an IP injection of …

Developmental neurotoxicology: history and outline of developmental neurotoxicity study guidelines

H Aoyama, N Takahashi, Y Shutoh, A Motomura… - Food Safety, 2015 - jstage.jst.go.jp
The present work provides a brief review of basic concepts in developmental
neurotoxicology, as well as current representative testing guidelines for evaluating …

Postnatal behavior in Hatano high-and low-avoidance rats following prenatal exposure to low-dose methylazoxymethanol

R Ohta, A Matsumoto, M Sato, M Shirota… - Neurotoxicology and …, 2000 - Elsevier
The hypothesis that genetic factors influence behavioral effects was tested in rats exposed
prenatally to methylazoxymethanol (MAM). We examined whether baseline behavior is an …

Evaluation of juvenile animal studies for pediatric CNS-targeted compounds: a regulatory perspective

JW van der Laan, K Van Malderen… - International …, 2019 - journals.sagepub.com
Central nervous system (CNS)-targeted products are an important category of pediatric
pharmaceuticals. In view of the significant postnatal maturation of the CNS, juvenile animal …