The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM
versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 …

Since the identification of microRNAs (miRNAs) in 1993, and the subsequent discovery of
their highly conserved nature in 2000, the amount of research into their function …

Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

The content of proteoglycans (PGs) is low in the extracellular matrix (ECM) of vascular
tissue, but increases dramatically in all phases of vascular disease. Early studies …

Vascular smooth muscle cells (VSMCs) are able to perform both contractile and synthetic
functions, which are associated with changes in morphology, proliferation, and migration …

Abstract miR-143 and miR-145 are co-expressed microRNAs (miRNAs) that have been
extensively studied as potential tumor suppressors. These miRNAs are highly expressed in …

Atherosclerosis is a chronic immune-inflammatory disorder that integrates multiple cell types
and a diverse set of inflammatory mediators. miRNAs are emerging as important post …

Alterations in the vascular smooth muscle cells (VSMC) phenotype play a critical role in the
pathogenesis of several cardiovascular diseases, including hypertension, atherosclerosis …

Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,
such as a heparan, dermatan, chondroitin, or keratan sulfate, covalently attached to the …