Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
Addiction as vulnerabilities in the decision process
AD Redish, S Jensen, A Johnson - Behavioral and brain sciences, 2008 - cambridge.org
In our target article, we proposed that addiction could be envisioned as misperformance of a
decision-making machinery described by two systems (deliberative and habit systems) …
decision-making machinery described by two systems (deliberative and habit systems) …
The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia
Neural oscillations and their synchronization may represent a versatile signal to realize
flexible communication within and between cortical areas. By now, there is extensive …
flexible communication within and between cortical areas. By now, there is extensive …
The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia
KY Tseng, RA Chambers, BK Lipska - Behavioural brain research, 2009 - Elsevier
Traditionally, animal models of schizophrenia were predominantly pharmacological
constructs focused on phenomena linked to dopamine and glutamate neurotransmitter …
constructs focused on phenomena linked to dopamine and glutamate neurotransmitter …
Long-lasting rescue of network and cognitive dysfunction in a genetic schizophrenia model
Although sensitizing processes occur earlier, schizophrenia is diagnosed in young
adulthood, which suggests that it might involve a pathological transition during late brain …
adulthood, which suggests that it might involve a pathological transition during late brain …
Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders
Prefrontal cortex (PFC) mediates an assortment of cognitive functions including working
memory, behavioral flexibility, attention, and future planning. Unlike the hippocampus …
memory, behavioral flexibility, attention, and future planning. Unlike the hippocampus …
Mechanisms of action and persistent neuroplasticity by drugs of abuse
ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - Elsevier
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …
important for the homeostasis of brain processes and for learning and remembering …
Evaluation of animal models of neurobehavioral disorders
FJ van der Staay, SS Arndt, RE Nordquist - Behavioral and Brain …, 2009 - Springer
Animal models play a central role in all areas of biomedical research. The process of animal
model building, development and evaluation has rarely been addressed systematically …
model building, development and evaluation has rarely been addressed systematically …
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1–ErbB4 and DISC1
H Jaaro-Peled, A Hayashi-Takagi, S Seshadri… - Trends in …, 2009 - cell.com
Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …
by susceptibility genes and environmental insults during early neurodevelopment initiate …
Rethinking schizophrenia in the context of normal neurodevelopment
The schizophrenia brain is differentiated from the normal brain by subtle changes, with
significant overlap in measures between normal and disease states. For the past 25 years …
significant overlap in measures between normal and disease states. For the past 25 years …