Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of
intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions …

During the establishment of neural circuitry axons often need to cover long distances to
reach remote targets. The stereotyped navigation of these axons defines the connectivity …

Mitochondria are key organelles for brain health. Mitochondrial alterations have been
reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and …

The presence of blood-brain barrier (BBB) and specificity of neuron targeting remain two
challenges in the effective delivery of nanotherapeutics for the treatment of Alzheimers …

Huntington's disease (HD) is characterized by protein inclusions and loss of striatal neurons
which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the …

Aims In this study we aimed to explore the specific effect and mechanism of oxymatrine on
neonatal rats hypoxic-ischemic brain damage. Materials and methods Hypoxia-ischemia …

Mitochondria are highly dynamic organelles with strict quality control processes that
maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated …

ABSTRACT HTT (huntingtin) is a 350-kDa protein of unknown function. While HTT moves
bidirectionally within axons and HTT loss/reduction causes axonal transport defects, the …

It is more than 25 years since the discovery that kinesin 1 is phosphorylated by several
protein kinases. However, fundamental questions still remain as to how specific protein …

Proper transport of the Parkinson's disease (PD) protein, α-synuclein (α-syn), is thought to
be crucial for its localization and function at the synapse. Previous work has shown that …