Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Many proteins contain intrinsically disordered regions (IDRs), functional polypeptide
segments that in isolation adopt a highly flexible conformational ensemble instead of a …

Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary
drivers of tumor formation and cancer progression. These alterations can endow cells with a …

Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS).
Components of this pathway, including the proteasome, ubiquitinating enzymes and …

Axin is a key scaffolding protein responsible for the formation of the β-catenin destruction
complex. Stability of Axin protein is regulated by the ubiquitin-proteasome system, and …

The p53 tumor suppressor protein and its major negative regulators MDM2 and MDMX
oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating …

The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …

Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in
various diseases including cancer and neurodegeneration. In this review, we recapitulate …