Many organisms that cause infectious diseases, particularly RNA viruses, mutate so rapidly
that their evolutionary and ecological behaviours are inextricably linked. Consequently …

Phylogenomics refers to the inference of historical relationships among species using
genome-scale sequence data and to the use of phylogenetic analysis to infer protein …

Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral
variants that can emerge to infect humans. In North America, there is phylogenomic …

The independent emergence late in 2020 of the B. 1.1. 7, B. 1.351, and P. 1 lineages of
SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to …

Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site
associated with viral production, storage of viral particles in immune complexes, and viral …

Relaxation of selective strength, manifested as a reduction in the efficiency or intensity of
natural selection, can drive evolutionary innovation and presage lineage extinction or loss of …

Datamonkey is a popular web-based suite of phylogenetic analysis tools for use in
evolutionary biology. Since the original release in 2005, we have expanded the analysis …

Wildlife reservoirs of SARS-CoV-2 can lead to viral adaptation and spillback from wildlife to
humans. In North America, there is evidence of spillover of SARS-CoV-2 from humans to …

Host species-specific fitness landscapes largely determine the outcome of host switching
during pathogen emergence. Using chikungunya virus (CHIKV) to study adaptation to a …

It is generally accepted that the extent of phenotypic change between human and great apes
is dissonant with the rate of molecular change. Between these two groups, proteins are …