Bioprocessing in the digital age: the role of process models
In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …
Current trends in fungal biosynthesis of chitin and chitosan
MM Abo Elsoud, EM El Kady - Bulletin of the National Research Centre, 2019 - Springer
Background Chitin and chitosan are natural biopolymers found in shell of crustaceans,
exoskeletons of insects and mollusks, as well as in the cell walls of fungi. These biopolymers …
exoskeletons of insects and mollusks, as well as in the cell walls of fungi. These biopolymers …
Estimating parameters of photovoltaic models using accurate turbulent flow of water optimizer
Recently, the use of diverse renewable energy resources has been intensively expanding
due to their technical and environmental benefits. One of the important issues in the …
due to their technical and environmental benefits. One of the important issues in the …
Artificial neural networks enable genome-scale simulations of intracellular signaling
Mammalian cells adapt their functional state in response to external signals in form of
ligands that bind receptors on the cell-surface. Mechanistically, this involves signal …
ligands that bind receptors on the cell-surface. Mechanistically, this involves signal …
[HTML][HTML] Modern day monitoring and control challenges outlined on an industrial-scale benchmark fermentation process
S Goldrick, CA Duran-Villalobos, K Jankauskas… - Computers & Chemical …, 2019 - Elsevier
This paper outlines real-world control challenges faced by modern-day biopharmaceutical
facilities through the extension of a previously developed industrial-scale penicillin …
facilities through the extension of a previously developed industrial-scale penicillin …
Parameter estimation in large-scale systems biology models: a parallel and self-adaptive cooperative strategy
Background The development of large-scale kinetic models is one of the current key issues
in computational systems biology and bioinformatics. Here we consider the problem of …
in computational systems biology and bioinformatics. Here we consider the problem of …
[HTML][HTML] Bioprocess systems engineering: transferring traditional process engineering principles to industrial biotechnology
The complexity of the regulatory network and the interactions that occur in the intracellular
environment of microorganisms highlight the importance in developing tractable mechanistic …
environment of microorganisms highlight the importance in developing tractable mechanistic …
Combining model structure identification and hybrid modelling for photo‐production process predictive simulation and optimisation
Integrating physical knowledge and machine learning is a critical aspect of developing
industrially focused digital twins for monitoring, optimisation, and design of microalgal and …
industrially focused digital twins for monitoring, optimisation, and design of microalgal and …
Analysis and design of a genetic circuit for dynamic metabolic engineering
N Anesiadis, H Kobayashi, WR Cluett… - ACS synthetic …, 2013 - ACS Publications
Recent advances in synthetic biology have equipped us with new tools for bioprocess
optimization at the genetic level. Previously, we have presented an integrated in silico …
optimization at the genetic level. Previously, we have presented an integrated in silico …
Advanced model‐based control strategies for the intensification of upstream and downstream processing in mAb production
MM Papathanasiou… - Biotechnology …, 2017 - Wiley Online Library
Current industrial trends encourage the development of sustainable, environmentally
friendly processes with minimal energy and material consumption. In particular, the …
friendly processes with minimal energy and material consumption. In particular, the …