[HTML][HTML] Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
The functional significance behind expressing two IL–8 receptor types on PMN
The presence of two CXCL8 receptor types combined with the inflammatory roles of PMN
has led to interest in whether each receptor type contributes to unique functions. PMN are …
has led to interest in whether each receptor type contributes to unique functions. PMN are …
[HTML][HTML] Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19
Neutrophils provide a critical line of defense in immune responses to various pathogens,
inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work …
inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work …
ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets
C Bizzarri, AR Beccari, R Bertini, MR Cavicchia… - Pharmacology & …, 2006 - Elsevier
ELR+ CXC chemokines, by direct interaction with their cell surface receptors CXC
chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2), are believed to …
chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2), are believed to …
Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils
S Chakrabarti, KD Patel - Journal of leukocyte biology, 2005 - academic.oup.com
Abstract Matrix metalloproteinase-9 (MMP-9) is present in the tertiary granules of neutrophils
and can be released following stimulation. We examined the signaling mechanisms that …
and can be released following stimulation. We examined the signaling mechanisms that …
Induction of human neutrophil chemotaxis by Candida albicans-derived β-1,6-long glycoside side-chain-branched β-glucan
T Sato, K Iwabuchi, I Nagaoka, Y Adachi… - Journal of leukocyte …, 2006 - academic.oup.com
Abstract Polysaccharide β-1, 3-D-glucans (β-glucans) are components of the cell wall of
various fungi and show immunomodulatory activities. β-Glucans have been reported to …
various fungi and show immunomodulatory activities. β-Glucans have been reported to …
Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile
AR Elia, P Cappello, M Puppo, T Fraone… - Journal of Leucocyte …, 2008 - academic.oup.com
Dendritic cells (DCs) are the most potent antigen-presenting cells and fine-tune the immune
response. We have investigated hypoxia's effects on the differentiation and maturation of …
response. We have investigated hypoxia's effects on the differentiation and maturation of …
Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2
F Casilli, A Bianchini, I Gloaguen, L Biordi… - Biochemical …, 2005 - Elsevier
Repertaxin is a new non-competitive allosteric blocker of interleukin-8 (CXCL8/IL-8)
receptors (CXCR1/R2), which by locking CXCR1/R2 in an inactive conformation prevents …
receptors (CXCR1/R2), which by locking CXCR1/R2 in an inactive conformation prevents …
Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2
HC Aasheim, J Delabie, EF Finne - Blood, 2005 - ashpublications.org
Eph receptors, the largest subfamily of receptor tyrosine kinases, and their ephrin ligands
are important mediators of cell-cell communication regulating cell attachment, shape, and …
are important mediators of cell-cell communication regulating cell attachment, shape, and …
Chemotactic antiviral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells
Mucosal epithelia provide strong barriers against pathogens. For instance, the outward
facing apical membrane of polarized epithelial cells lacks receptors for agents, such as …
facing apical membrane of polarized epithelial cells lacks receptors for agents, such as …