Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to
activated Protein C and an increased risk for venous thromboembolism. Deep venous …

Thrombophilia is defined as a condition predisposing to the development of venous
thromboembolism (VTE) on the basis of a hypercoagu-lable state. Over the past decades …

Introduction: Fifty-three years after the first description of an inherited prothrombotic
condition (antithrombin deficiency), our knowledge on hereditary and acquired causes of …

The use of modern laboratory instrumentation with high levels of test reliability and
appropriate quality assurance measures will lead to very few analytical errors within …

Introduction Natural anticoagulants deficiency (antithrombin [AT], protein C [PC], protein S
[PS]) is a rare, but potent risk factor for venous thromboembolism (VTE). We performed a …

This review provides an update on laboratory testing and monitoring for existing and
emerging anticoagulants, starting with an overview of haemostasis and the routine …

Venous thromboembolic disease in childhood is a multifactorial disease. Risk factors
include acquired clinical risk factors such as a central venous catheter and underlying …

Hemostasis is a complex and tightly regulated process whereby the body attempts to
maintain a homeostatic balance to permit normal blood flow, without bleeding or thrombosis …

Thrombophilia can be broadly defined as an increased tendency toward hypercoagulability
and venous thrombosis. There are several defined risk factors for thrombosis, and these are …

Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism,
is a leading health-care problem whose pathogenesis is usually related to the so-called …