[HTML][HTML] Blood–brain barrier dynamics to maintain brain homeostasis

M Segarra, MR Aburto, A Acker-Palmer - Trends in neurosciences, 2021 - cell.com
The blood–brain barrier (BBB) is a dynamic platform for exchange of substances between
the blood and the brain parenchyma, and it is an essential functional gatekeeper for the …

Optic nerve ultrasound evaluation in animals and normal subjects

L Vitiello, M De Bernardo, L Capasso, P Cornetta… - Frontiers in …, 2022 - frontiersin.org
In recent years, ultrasonographic measurement of the optic nerve sheath diameter (ONSD)
has been widely used to identify the presence of increased intracranial pressure (ICP) …

High-altitude hypoxia induced reactive oxygen species generation, signaling, and mitigation approaches

P Gaur, S Prasad, B Kumar, SK Sharma… - International Journal of …, 2021 - Springer
Homeostasis between pro-oxidants and anti-oxidants is necessary for aerobic life, which if
perturbed and shifted towards pro-oxidants results in oxidative stress. It is generally agreed …

[HTML][HTML] High-altitude illnesses: old stories and new insights into the pathophysiology, treatment and prevention

M Burtscher, U Hefti, JP Hefti - Sports Medicine and Health Science, 2021 - Elsevier
Areas at high-altitude, annually attract millions of tourists, skiers, trekkers, and climbers. If not
adequately prepared and not considering certain ascent rules, a considerable proportion of …

Effects of prolonged exposure to hypobaric hypoxia on oxidative stress: overwintering in Antarctic Concordia Station

S Mrakic-Sposta, M Montorsi, S Porcelli… - Oxidative Medicine …, 2022 - Wiley Online Library
Concordia Station is the permanent, research station on the Antarctic Plateau at 3230 m.
During the eleventh winter‐over campaign (DC11‐2015; February 2015 to November 2015) …

Genistein prevents hypoxia-induced cognitive dysfunctions by ameliorating oxidative stress and inflammation in the hippocampus

M Rumman, S Pandey, B Singh, M Gupta, S Ubaid… - Neurotoxicity …, 2021 - Springer
Abstract Genistein (GE), a plant-derived isoflavone, is a polyphenolic non-steroidal
compound. Studies showed that GE possesses anti-cancer, anti-inflammatory, anti …

[HTML][HTML] The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

X Chen, X Zhao, H Cai, H Sun, Y Hu, X Huang, W Kong… - Redox Biology, 2017 - Elsevier
Age-related dysfunction of the central auditory system, known as central presbycusis, is
characterized by defects in speech perception and sound localization. It is important to …

Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: A field study in the Alps

S Mrakic-Sposta, M Gussoni, C Dellanoce… - European journal of …, 2021 - Springer
Purpose High altitude results in lower barometric pressure and hence partial pressure of O 2
decrease can lead to several molecular and cellular changes, such as generation of reactive …

Advances in the available non-biological pharmacotherapy prevention and treatment of acute mountain sickness and high altitude cerebral and pulmonary oedema

KE Joyce, SJE Lucas, CHE Imray… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: The physiological responses on exposure to high altitude are relatively well
known, but new discoveries are still being made, and novel prevention and treatment …

Oscillatory shear stress, flow-mediated dilatation, and circulating microparticles at sea level and high altitude

JC Tremblay, SR Thom, M Yang, PN Ainslie - Atherosclerosis, 2017 - Elsevier
Background and aims Exposing the endothelium to acute periods of imposed oscillatory
shear stress reduces endothelial function and elevates circulating microparticles (MPs) …