Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …

Ester bond hydrolysis of membrane phospholipids by Phospholipase A2 and consequent
release of fatty acids are the initiating steps of inflammation. It is proposed in this study that …

The massive technical and computational progress of biomolecular crystallography has
generated some adverse side effects. Most crystal structure models, produced by …

As a result of substantial instrumental automation and the continuing improvement of
software, crystallographic studies of biomolecules are conducted by non-experts in …

Snakebite envenomation is a serious health concern in tropical regions, resulting in high
mortality. The World Health Organization (WHO) has declared it a neglected tropical disease …

Phospholipase A₂ (PLA₂) is a ubiquitous enzyme that specifically catalyzes hydrolysis of
membrane phospholipids to produce lysophospholipids and free fatty acid, namely …

Structure-guided design was employed in a search for potent and selective inhibitors of
mammalian secreted phospholipases A2 (sPLA2s). Using the X-ray structures of human …

Phospholipase A2 is potentially an important target for structure-based rational drug design.
In order to determine the involvement of phospholipase A2 in the action of non-steroidal anti …

Snake venom, particularly of vipers from the Indian subcontinent, contains Phospholipase
A2 (PLA2) as one its constituents which is widely implicated in hemorrhagic, cardiac arrest …

Type IIA secretory phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of the sn-2
ester bond of glycerophospholipids to release fatty acids and lysophospholipids. In order to …