Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …

Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been
rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin …

Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin
resistance and progressively reduced insulin secretion, which leads to impaired glucose …

Effective interventions and treatments for complex diseases have been implemented
globally, however, coverage in Africa has been comparatively lower due to lack of capacity …

Abstract Background Type 2 diabetes (T2D) is a worldwide epidemic with considerable
health and economic consequences. Sulfonylureas are widely used drugs for the treatment …

Background: Type 2 Diabetes Mellitus (T2DM) is a worldwide disorder as the most important
challenges of health-care systems. Controlling the normal glycaemia greatly profit long-term …

Diabetes is a major health problem worldwide. Glycemic control is the main goal in the
management of type 2 diabetes. While many anti-diabetic drugs and guidelines are …

The clinical response to sulphonylurea, an oral antidiabetic agent often used in combination
with metformin to control blood glucose in type 2 diabetes (T2DM) patients, has been widely …

Background Insulin receptor substrate-1 (IRS1) plays a critical role in insulin signaling. IRS-
1 gene polymorphism with glycine to arginine substitution (GGG↔ AGG substitutions) in …

Background and purpose: Multidrug and toxin extrusion transporter 1 (MATE1), encoded by
the SLC47A1 gene and single nucleotide polymorphisms of organic cation transport 1, may …