To study complex biological processes holistically, it is imperative to take an integrative
approach that combines multi-omics data to highlight the interrelationships of the involved …

In the big data era, voluminous datasets are routinely acquired, stored and analyzed with the
aim to inform biomedical discoveries and validate hypotheses. No doubt, data volume and …

Whole exome sequencing has been increasingly used in human disease studies.
Prioritization based on appropriate functional annotations has been used as an …

Abstract The BioMart Community Portal (www. biomart. org) is a community-driven effort to
provide a unified interface to biomedical databases that are distributed worldwide. The …

How species with similar repertoires of protein-coding genes differ so markedly at the
phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate …

ABSTRACT dbNSFP is a database developed for functional prediction and annotation of all
potential non‐synonymous single‐nucleotide variants (nsSNVs) in the human genome. This …

Biotic and abiotic stresses limit agricultural yields, and plants are often simultaneously
exposed to multiple stresses. Combinations of stresses such as heat and drought or cold …

Abstract The International Cancer Genome Consortium (ICGC) is a collaborative effort to
characterize genomic abnormalities in 50 different cancer types. To make this data …

Poly morphisms in mi cro R NAs (miRNAs) and their t arget s ites (PolymiRTS) are known to
disrupt miRNA function, leading to the development of disease and variation in physiological …

Mutations in genes encoding splicing factors (which we refer to as spliceosomal genes) are
commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid …