T‐cell activation is mediated by antigen‐specific signals from the TCRζ/CD3 and CD4–CD8–
p56lck complexes in combination with additional co‐signals provided by coreceptors such …

Recent genetic evidence has established a pathogenetic role for NF-κB signaling in cancer.
NF-κB signaling is engaged transiently when normal B lymphocytes respond to antigens, but …

Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's
lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is …

CD28 costimulation regulates a wide range of cellular processes, from proliferation and
survival to promoting the differentiation of specialized T-cell subsets. Since first being …

Background Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold
protein in lymphocytes that links antigen receptor engagement with downstream signaling to …

The signaling pathway controlling antigen receptor-induced regulation of the transcription
factor NF-κB plays a key role in lymphocyte activation and development and the generation …

The paracaspase MALT1 is pivotal in antigen receptor–mediated lymphocyte activation and
lymphomagenesis. MALT1 contains a caspase-like domain, but it is unknown whether this …

The NF-κB family of transcription factors plays a crucial role in cell activation, survival and
proliferation. Its aberrant activity results in cancer, immunodeficiency or autoimmune …

Derangement of the nuclear factor κB (NF‐κB) pathway initiates and/or sustains many types
of human cancer. B‐cell malignancies are particularly affected by oncogenic mutations …

The scaffold proteins CARMA1-3 (encoded by the genes CARD11,-14 and-10) and CARD9
play major roles in signaling downstream of receptors with immunoreceptor tyrosine …