Current and future clinical applications of ctDNA in immuno-oncology

JC Stadler, Y Belloum, B Deitert, M Sementsov… - Cancer Research, 2022 - AACR
Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive
opportunity to diagnose, characterize, and monitor the disease in individual cancer patients …

Recent advancements in the application of circulating tumor DNA as biomarkers for early detection of cancers

M Mishra, R Ahmed, DK Das… - ACS Biomaterials …, 2024 - ACS Publications
Early detection of cancer is vital for increasing patient survivability chances. The three major
techniques used to diagnose cancers are instrumental examination, tissue biopsy, and …

Metastatic melanoma: liquid biopsy as a new precision medicine approach

E Ricciardi, E Giordani, G Ziccheddu, I Falcone… - International journal of …, 2023 - mdpi.com
Precision medicine has driven a major change in the treatment of many forms of cancer. The
discovery that each patient is different and each tumor mass has its own characteristics has …

Incidental detection of FGFR3 fusion via liquid biopsy leading to earlier diagnosis of urothelial carcinoma

Q Huang, I Mitsiades, H Dowst… - NPJ Precision …, 2023 - nature.com
The rising utilization of circulating tumor DNA (ctDNA) assays in Precision Oncology may
incidentally detect genetic material from secondary sources. It is important that such findings …

Circulating tumor DNA as a cancer biomarker: an overview of biological features and factors that may impact on ctDNA analysis

E Sánchez-Herrero, R Serna-Blasco… - Frontiers in …, 2022 - frontiersin.org
Cancer cells release nucleic acids, freely or associated with other structures such as
vesicles into body fluids, including blood. Among these nucleic acids, circulating tumor DNA …

NPY Methylated ctDNA is a Promising Biomarker for Treatment Response Monitoring in Metastatic Colorectal Cancer

K Janssens, G Vanhoutte, W Lybaert, W Demey… - Clinical Cancer …, 2023 - AACR
Purpose: Analysis of methylation markers in liquid biopsies is a promising technique for the
follow-up of patients with metastatic colorectal cancer (mCRC), because they can be used in …

Toward an efficient deep learning model for lung pathologies detection in X-Ray images

A Souid, N Sakli, H Sakli - 2022 International Wireless …, 2022 - ieeexplore.ieee.org
Medical imaging methods identify and record anomalies in the human body. These
techniques are critical for assessing, diagnosing, and treating lung illnesses. Chest …

Harnessing ctDNA in advanced melanoma: a promising tool for informed clinical decisions

R Pikturniene, A Cesas, S Jarmalaite, A Razbadauskas… - Cancers, 2024 - mdpi.com
Simple Summary Cutaneous melanoma, a fatal and aggressive tumor, has witnessed a
transformative shift in its clinical management over the past decade with the advent of anti …

Tumour-informed liquid biopsies to monitor advanced melanoma patients under immune checkpoint inhibition

C Schroeder, S Gatidis, O Kelemen, L Schütz… - Nature …, 2024 - nature.com
Immune checkpoint inhibitors (ICI) have significantly improved overall survival in melanoma
patients. However, 60% experience severe adverse events and early response markers are …

The prognostic value of a single, randomly timed circulating tumor DNA measurement in patients with metastatic melanoma

A Boerlin, E Bellini, P Turko, PF Cheng, MP Levesque… - Cancers, 2022 - mdpi.com
Simple Summary In this study, we investigated the associations of circulating tumor DNA
(ctDNA), measured at a random time point during the patient's treatment, with tumor …