Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions …

The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

While many germline cancer risk variants have been identified through genome-wide
association studies (GWAS), the mechanisms by which these variants operate remain …

Domestic dogs are unique from other animal models of cancer in that they generally
experience spontaneous disease. In addition, most types of cancer observed in humans are …

In 2006 the National Institutes of Health (NIH) established the Clinical and Translational
Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage …

Mutations in enhancer‐associated chromatin‐modifying components and genomic
alterations in non‐coding regions of the genome occur frequently in cancer, and other …

Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its
dysregulation is implicated in both ageing and age-associated diseases in human. Cross …

Background & Aims Single nucleotide polymorphisms could affect risk for hepatitis B virus
(HBV)-related hepatocellular carcinoma (HCC). We performed a germline copy number …

Breast cancer is one of the most common cancers among women, and susceptibility is
explained by genetic, lifestyle and environmental components. Copy Number Variants …

Transcription is the fundamental process in all living organisms. A variety of important
proteins, such as NRs, BETs, HDACs and many others are involved in transcription process …