This review examined the origins of the concept of the BMI in the work of Quetelet in the 19th
century and its subsequent adoption and use in tracking the course of the pandemic of …

Modern health care faces several serious challenges, including an ageing population and
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …

Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to
host metabolism, immune regulation and integrity of the intestinal epithelium. However, the …

Population-level variation and mechanisms behind insulin secretion in response to
carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin …

Obesity is a complex and heterogeneous condition that leads to various metabolic
complications, including type 2 diabetes. Unfortunately, for some, treatment options to date …

Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …

On average, aging is associated with unfavorable changes in cellular metabolism, which are
the processes involved in the storage and expenditure of energy. However, metabolic …

Frailty, a multidimensional indicator of suboptimal aging, reflects cumulative declines across
multiple physiological systems. Although age-related changes have been reported in gut …

Obesity is a complex and multifactorial condition that poses significant health risks. Recent
advancements in our understanding of obesity have highlighted the heterogeneity within this …

Background The influence of genetics and environment on the association of the plasma
proteome with body mass index (BMI) and changes in BMI remains underexplored, and the …