[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease

Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

[HTML][HTML] Roles of melatonin in the field of reproductive medicine

W Yong, H Ma, M Na, T Gao, Y Zhang, L Hao… - Biomedicine & …, 2021 - Elsevier
Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …

More than a marker: potential pathogenic functions of MAP2

RA DeGiosio, MJ Grubisha, ML MacDonald… - Frontiers in molecular …, 2022 - frontiersin.org
Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Cellular mechanisms of melatonin: insight from neurodegenerative diseases

D Chen, T Zhang, TH Lee - Biomolecules, 2020 - mdpi.com
Neurodegenerative diseases are the second most common cause of death and
characterized by progressive impairments in movement or mental functioning in the central …

Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways

SR Pandi-Perumal, I Trakht, V Srinivasan… - Progress in …, 2008 - Elsevier
Melatonin, an endogenous signal of darkness, is an important component of the body's
internal time-keeping system. As such it regulates major physiological processes including …

[HTML][HTML] Distribution, function and physiological role of melatonin in the lower gut

CQ Chen, J Fichna, M Bashashati, YY Li… - World journal of …, 2011 - ncbi.nlm.nih.gov
Melatonin is a hormone with endocrine, paracrine and autocrine actions. It is involved in the
regulation of multiple functions, including the control of the gastrointestinal (GI) system under …

Melatonin anticancer effects

G Di Bella, F Mascia, L Gualano, L Di Bella - International journal of …, 2013 - mdpi.com
Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal
gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and …

Microtubule and microtubule associated protein anomalies in psychiatric disease

F Marchisella, ET Coffey, P Hollos - Cytoskeleton, 2016 - Wiley Online Library
Anomalies in neuronal cell architecture, in particular dendritic complexity and synaptic
density changes, are widely observed in the brains of subjects with schizophrenia or mood …

Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

R An, L Zhao, C Xi, H Li, G Shen, H Liu… - Basic Research in …, 2016 - Springer
Myocardial dysfunction is an important manifestation of sepsis. Previous studies suggest that
melatonin is protective against sepsis. In addition, activation of the phosphatidylinositol 3 …

Melatonin improves d‐galactose‐induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB …

DY Yoo, W Kim, CH Lee, BN Shin… - Journal of pineal …, 2012 - Wiley Online Library
Melatonin (N‐acetyl‐5‐methoxytryptamine) has multiple functions. In this study, we
investigated the effects of melatonin on memory, cell proliferation, and neuroblast …