ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling
platforms that drive cellular transformation upon integrin-dependent adhesion and growth …

The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular
signaling events. Although these proteins do not have enzymatic or transcriptional activity …

Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic
features and the consistent expression of CD30. It then became evident that the majority of …

Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-
L, EFS/SIN and CASS4/HEPL) are integral players in normal and pathological cell biology …

Insulin receptor substrates (IRSs) are adaptor proteins that link signaling from upstream
activators to multiple downstream effectors to modulate normal growth, metabolism, survival …

Anaplastic large cell lymphomas (ALCLs) represent a subset of lymphomas in which the
anaplastic lymphoma kinase (ALK) gene is frequently fused to the nucleophosmin (NPM) …

Context—The year 2010 commemorates the 25th year since the seminal publication by Karl
Lennert and Harald Stein and others in Kiel, West Germany, describing an unusual large …